Demonstrated Efficacy – Pre-Clinical with Study Sustained Delivery Device
Demonstrated Efficacy – Pre-Clinical Study with
Sustained Delivery Device
9 Sheep Implanted With a Biofilm-contaminated Plate
(each with ~3 billion bacteria)
9 Sheep Implanted
With a Biofilm-contaminated Plate
(each with
~3 billion bacteria)
TREATMENT
RESULTS AFTER 21 DAYS
2 sheep received NO ANTIBIOTICS as control
More than 100,000,000 bacteria
INFECTED
2 sheep received
NO ANTIBIOTICS
as control
More than 100,000,000 bacteria
INFECTED
2 sheep received ANTIBIOTICS INTRAVENOUSLY
More than 100,000,000 bacteria
INFECTED
2 sheep received
ANTIBIOTICS
INTRAVENOUSLY
More than 100,000,000 bacteria
INFECTED
5 sheep received ANTIBIOTICS VIA PURGO POUCH
Less than 1,000 bacteria
NOT INFECTED*
5 sheep received
ANTIBIOTICS VIA
PURGO POUCH
Less than 1,000 bacteria
NOT INFECTED*
* Infectious dose is clinically defined as 105 CFU or 100,000 bacteria.
TREATMENT
2 sheep received
NO ANTIBIOTICS as control
RESULTS AFTER 21 DAYS
More than 100,000,000 bacteria
INFECTED
TREATMENT
2 sheep received
ANTIBIOTICS INTRAVENOUSLY
RESULTS AFTER 21 DAYS
More than 100,000,000 bacteria
INFECTED
TREATMENT
5 sheep received
ANTIBIOTICS VIA PURGO POUCH
RESULTS AFTER 21 DAYS
Less than 1,000 bacteria
NOT INFECTED*
* Infectious dose is clinically defined as
105 CFU or 100,000 bacteria.
Purgo Pouch Eradicated Greater Than 99.999% of Bacteria
Purgo Pouch Eradicated Greater Than 99.999% of Bacteria
Superior to – Existing Options
Superior to –
Existing Options
| SSI Treatment Options | Effective to Control Planktonic Bacteria | Adjustable Dosing | Flexibility to Change Antibiotics | Daily at Home Management | *Effective Biofilm Eradication |
|---|---|---|---|---|---|
| Sustained Delivery Device | |||||
| Oral or IV Antibiotics Administration | |||||
| Localized Antibiotic Infusion | |||||
| Stimulan Beads with Antibiotics | |||||
| Antibiotic Powders Placed in Wound or Surgical Incision |
| SSI Treatment Options | Effective to Control Planktonic Bacteria | Adjustable Dosing | Flexibility to Change Antibiotics | Daily at Home Management | *Effective Biofilm Eradication |
|---|---|---|---|---|---|
| Sustained Delivery Device | |||||
| Oral or IV Antibiotics Administration | |||||
| Localized Antibiotic Infusion | |||||
| Stimulan Beads with Antibiotics | |||||
| Antibiotic Powders Placed in Wound or Surgical Incision |
*As demonstrated in sheep models.