SURGICAL SITE INFECTION
Why is it So Hard to Manage?
“The global impact of surgical site infections is monumental and as many as 80% of these infections may involve a microbial biofilm.”
Edmiston C.E., McBain A.J., Roberts C., Leaper D. (2015) Clinical and Microbiological Aspects of Biofilm-Associated Surgical Site Infections. In: Donelli G. (eds) Biofilm-based Healthcare-associated Infections. Advances in Experimental Medicine and Biology, vol 830. Springer, Cham. doi.org/10.1007/978-3-319-11038-7_3
“When encased in biofilms in the human body, bacteria are a thousand times less susceptible to antibiotics.”
Adam Hadhazy for the Office of Engineering Communications (2016) Scientists get their first look into how bacteria construct a slimy biofilm fortress.
“Surgical site infection is disastrous in orthopedic practice as it is difficult to rid the bone and joint of the infection.”
Prevalence of Surgical Site Infection in Orthopedic Surgery: A 5-year Analysis – June 2014, International Surgery – Official Journal of the International College of Surgeons
“The global impact of surgical site infections is monumental and as many as 80% of these infections may involve a microbial biofilm.”
Edmiston C.E., McBain A.J., Roberts C., Leaper D. (2015) Clinical and Microbiological Aspects of Biofilm-Associated Surgical Site Infections. In: Donelli G. (eds) Biofilm-based Healthcare-associated Infections. Advances in Experimental Medicine and Biology, vol 830. Springer, Cham. doi.org/10.1007/978-3-319-11038-7_3
“When encased in biofilms in the human body, bacteria are a thousand times less susceptible to antibiotics.”
Adam Hadhazy for the Office of Engineering Communications (2016) Scientists get their first look into how bacteria construct a slimy biofilm fortress.
“Surgical site infection is disastrous in orthopedic practice as it is difficult to rid the bone and joint of the infection.”
Prevalence of Surgical Site Infection in Orthopedic Surgery: A 5-year Analysis – June 2014, International Surgery – Official Journal of the International College of Surgeons
“The global impact of surgical site infections is monumental and as many as 80% of these infections may involve a microbial biofilm.”
Edmiston C.E., McBain A.J., Roberts C., Leaper D. (2015) Clinical and Microbiological Aspects of Biofilm-Associated Surgical Site Infections. In: Donelli G. (eds) Biofilm-based Healthcare-associated Infections. Advances in Experimental Medicine and Biology, vol 830. Springer, Cham. doi.org/10.1007/978-3-319-11038-7_3
“When encased in biofilms in the human body, bacteria are a thousand times less susceptible to antibiotics.”
Adam Hadhazy for the Office of Engineering Communications (2016) Scientists get their first look into how bacteria construct a slimy biofilm fortress.
“Surgical site infection is disastrous in orthopedic practice as it is difficult to rid the bone and joint of the infection.”
Prevalence of Surgical Site Infection in Orthopedic Surgery: A 5-year Analysis – June 2014, International Surgery – Official Journal of the International College of Surgeons
FDA – The State of Orthopedic Device-Related Infections Today
“First of all, once a biofilm forms there is currently NOTHING out there that will eliminate it, other than surgically removing it.”
David W. Lowenberg, MD
Clinical Professor of Orthopedic Surgery
Stanford University School of Medicine
“Continuing to use the same open fracture care tactics we’ve employed for the last 25 years is unlikely to result in different outcomes over the next 25 years. It’s time to change things up”
Michael J. Bosse, MD
Emeritus Professor
Atrium Health Musculoskeletal Institute
“First of all, once a biofilm forms there is currently NOTHING out there that will eliminate it, other than surgically removing it.”
David W. Lowenberg, MD
Clinical Professor of Orthopedic Surgery Stanford University School of Medicine
“Continuing to use the same open fracture care tactics we’ve employed for the last 25 years is unlikely to result in different outcomes over the next 25 years. It’s time to change things up”
Michael J. Bosse, MD
Emeritus Professor
Atrium Health Musculoskeletal Institute
CAUSES OF INFECTION
PLANKTONIC vs BIOFILM
What are Planktonic Bacteria?
- Individual bacteria.
- Float in a liquid medium like blood.
- Metabolically active.
- More susceptible to antibiotics.
- Readily controlled by host immune cells.
What are Bacterial Biofilms?
- Communities of bacteria.
- Primarily attach to solid surfaces.
- Metabolically inactive
- High tolerance to antibiotics.
- Can cause recurring infections.
What are Planktonic Bacteria?
- Individual bacteria.
- Float in a liquid medium like blood.
- Metabolically active.
- More susceptible to antibiotics.
- Readily controlled by host immune cells.
What are Bacterial Biofilms?
- Communities of bacteria.
- Primarily attach to solid surfaces.
- Metabolically inactive.
- High tolerance to antibiotics.
- Can cause recurring infections.
What are Planktonic Bacteria?
- Individual bacteria.
- Float in a liquid medium like blood.
- Metabolically active.
- More susceptible to antibiotics.
- Readily controlled by host immune cells.
What are Bacterial Biofilms?
- Communities of bacteria.
- Primarily attach to solid surfaces.
- Metabolically inactive.
- High tolerance to antibiotics.
- Can cause recurring infections.